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Healthcare providers should document all supplements and compounded preparations patients are using (including full ingredient lists and lot numbers), counsel on proper injection technique and site rotation, and monitor for unexpected adverse effects

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[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility

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