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Saxenda still has a place its FDA-approved for adolescents 12+ (Zepbound is adult-only), and some patients tolerate liraglutide better than tirzepatide

Coverage criteria can also be restrictive, requiring specific BMI thresholds or documented comorbidities, like sleep apnea and hypertension

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Quantitative PK/PD models may then be developed by combining in vivo pharmacodynamic (PD) data from zebrafish with metabolism data from in vitro human liver microsomes, enabling more accurate dose extrapolation (Arjmand et al., 2020

Ive recommended a tonne of friends because of that and I have never heard a negative review of the clinic