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In 2009, a double-blind randomised-controlled trial (RCT) found significant reductions in duration of outbreaks, the number of ulcers and the level of pain in those on B12, 1000 g per day sublingually (form not reported), regardless of B12 level

10.1016/0163-7258(90)90094-i 3 Allende-VegaN.Marco BruallaJ.FalvoP.AlexiaC.ConstantinidesM.de MaudaveA

Instead of paying the full amount upfront, researchers can receive their compounds immediately and spread the cost over time

If you have this variant, it is important to avoid folic acid in food and in supplements and only take methylfolate or 5-MTHF

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