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Research Findings Tesamorelin has been studied in hypothalamic-pituitary axis signaling, hepatic metabolic pathway, and body composition research models, with peer-reviewed laboratory literature characterizing its interactions with GHRH receptor binding mechanisms, pulsatile GH secretion dynamics, and IGF-1 axis modulation in preclinical and controlled investigational settings

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As this data is based on a simulation, not a patient-cohort or randomised clinical trial, the authors stressed its limitations