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In February, researchers from the University of Leicester and the Leicester Diabetes Centre published a review article on obesity in the "International Journal of Obesity," introducing the current and future drug development pipeline for the treatment of obesity, with special attention given to novel therapies based on the mechanisms of gut incretin hormones

At the same time, in 2002, Gipr knockout mice were found to be protected against both obesity and insulin resistance induced by high-fat feeding (53)

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However, the SmPCs for these medications include important cautions regarding use in patients with significant gastrointestinal disease

and Scharf, J-G