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Collectively, this approach was designed to provide a comprehensive, balanced, and mechanistically coherent synthesis of the existing evidence, while acknowledging variability in study quality, extract standardization, and clinical methodology across the literature

As collagen production increases, the skin becomes smoother, firmer, and more resilient

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52 Over-the-counter vitamin A and topicals made with natural retinoids have milder side effects than synthetic retinoids, but are also less likely to have beneficial effects

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