We followed PRISMA guidelines for systematic reviews to ensure transparency and completeness in our reporting [14]
Personal or family history of medullary thyroid carcinoma, MEN 2 syndrome, pregnancy, breastfeeding, or active pancreatitis are absolute contraindications regardless of dose
GLP-1 receptor agonists, a class of medications including semaglutide and tirzepatide, are injectable medications used in certain FDA-approved products for blood sugar management and chronic weight management, depending on the medication and indication
There have been reports of particularly severe acute pancreatitis, including necrotising and fatal pancreatitis, however, they are uncommon
Oral formulation : Both have oral formulations, but semaglutide's (Rybelsus) requires strict fasting conditions while VK2735's oral version may have fewer restrictions (though final labeling is unknown)