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Cell 132 , 344362 (2008)

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9 Distinguishing failed biology from failed pharmacology: a decision framework A central objective of this review is to distinguish peptidereceptor systems that were abandoned due to intrinsic biological limitations from those that failed primarily because of incomplete pharmacologic execution

Additionally, some individuals taking Mounjaro may have pre-existing conditions that independently increase their risk of B12 deficiency, such as previous bariatric surgery or concurrent metformin use (the MHRA has highlighted that metformin can reduce vitamin B12 levels)

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