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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves

The FTO rs9939609 variant predisposes some individuals to higher baseline hunger signals and greater difficulty with appetite control, even when taking appetite-suppressing medications

doi: 10.1128/spectrum.04370-22 68 IshikawaH.MatsumotoS.OhashiY.ImaokaA.SetoyamaH.UmesakiY.et al

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However, the recovery trajectory is not uniform