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In the SURMOUNT-1 trial at the highest dose, lean mass decreased by 5.67 kg or 10.9% from baseline, with only 25.7% of total weight lost coming from lean mass
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26 Experiments in pancreatic islets reveal that -arrestin limits the insulin response to GLP-1, but not GIP or tirzepatide, suggesting that the biased agonism and imbalance of tirzepatide toward the GIP receptor and its unique GLP-1 receptor signaling properties might be at the basis of its potent action
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