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For example, the Vd of diazepam, lorazepam, and nitrazepam decreased by 3.2-, 1.7-, and 2.1-fold, respectively, in non-obese participants, and their CL and t 1/2 were altered, indicating the need for dose adjustment

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Furthermore, GIPR antagonists increase metabolism in obese mice, and when combined with GLP1RAs, both GIPR agonists and antagonists have beneficial therapeutic effects

The 9mg dose in GLORY-2 showed impressive results, and even higher doses may be studied