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Reducing BDNF levels by producing conventional BDNF homozygous (/) knockout mice is not practical for this purpose, because such mice do not survive to adulthood 22 and the use of BDNF heterozygous (+/) mice have previously resulted in conflicting findings

[PUBMED Abstract] Falchi M, Bataille V, Hayward NK, et al.: Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi

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