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Role of phenolic OH and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin

Extremely high doses have not been well-studied for long-term safety

Collectively, these findings highlight the regulatory capacity of ZHX2 as a potential therapeutic target for attenuating DM-related hepatic injuries

Together, these findings reveal that global GPR146 deficiency leads to suppression of hepatic PPAR signaling and its downstream adipogenic targets, along with reduced expression of inflammatory and ECM remodeling genes