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Nrf2, nuclear factor erythroid 2-related factor 2

qPCR analysis confirmed that Rf regulates critical genes, including ANXA2, BAZ1A, DNMT3L, and MMP9, thereby clarifying its underlying mechanism of action

For example, senescent astrocytes show upregulated expression of IL-6, IL-8, IL-1, MMP3, MMP10, and TIMP2, while neuroprotective factors such as IL-10, NGF (nerve growth factor), and BDNF (brain-derived neurotrophic factor) are downregulated (Lye et al., 2019)

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Titrate the dose based upon the individual patients response to their initial dose of oxycodone and acetaminophen tablets