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Therapeutic doses for weight loss range from 0.25 mg to 2.4 mg weekly, while animal studies show severe toxicity only at doses 50 to 100 times higher than standard human treatment levels

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By contrast, in the United States, most insurance companies only approve GLP-1s for one year, despite its status as a long-term medication. The criteria for coverage in the United States vary greatly depending on BMI and comorbidities