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Results Enrollment and baseline demographics Herein we report results of a phase 1 clinical trial (www.clinicaltrials.gov, NCT02943239), involving a randomized, double-blind, placebo-controlled comparison assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of the GDF8 mAb, trevogrumab, and the ActA mAb, garetosmab, each given alone, as well as the GDF8 mAb given in combination with increasing dose levels of the ActA mAb

Epigenetic alterations in osteosarcoma: promising targets

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STEP 1 (Wilding et al., NEJM 2021) enrolled 1,961 adults with overweight or obesity , and explicitly excluded those with diabetes