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It has been demonstrated that increasing ROS could easily result in dysfunctions of proliferation or differentiation in AML, and could be an effective strategy for overcoming drug resistance in leukemia [21]

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Second, standardized safety evaluation frameworks including long-term biodistribution, immunogenicity, and clearance studies should be aligned with FDA/EMA guidelines to reduce regulatory uncertainty

Moving forwards, it would be beneficial for further research to progress to larger animal models