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36,38,39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation

Because its primary mechanisms involve circulating through the bloodstream and signaling cells throughout the body supporting collagen production in the skin, hair follicle health on the scalp, and tissue remodeling in joints and connective tissue all at once a delivery method that reaches systemic circulation efficiently is arguably better matched to how GHK-Cu actually works than a localized injection