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(1988) characterized IGFBP binding determinants in the IGF-1 molecule, providing the structural basis for the R3 substitution that became the foundation of the LR3 design (PMID 3356790)
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3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD
Patients with a history of thyroid cancer, multiple endocrine neoplasia type 2, or severe pancreatitis should avoid GLP-1 agonists entirely, regardless of dose
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