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Glucuronidation Increases BUT Is Insufficient While glucuronidation (the other safe pathway) does increase during pregnancy: This increase in glucuronidation CANNOT compensate for the simultaneous: 33% decrease in sulfation (another safe pathway) 80% increase in oxidation to toxic NAPQI **The Result:** When both safe pathways become saturated or overwhelmed, significantly more acetaminophen is forced through the toxic CYP2E1 pathway, creating 43% more NAPQIat precisely the time when glutathione reserves are most depleted

Sherman, J

Preclinical Studies in Ototoxicity Models A study carried out both in cultured cells and in an animal model (male and female mice) demonstrated the strong beneficial potential of ALA in rescuing ototoxic hearing loss caused by cisplatin

Some are exaggerated