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This is more common in people with pre-existing digestive sensitivities, those taking high doses of other fiber supplements, or individuals whose baseline microbiome was significantly different from the profile Pendulum is trying to create

Baseline microbial profiling may eventually contribute to understanding variability in GLP-1 RA response, but its routine use for therapeutic stratification is not supported by current evidence

The safety profile observed in animal studies is favorable, with no significant toxicity reported at the doses studied

It is important to know that everyone responds differently to medications

Oral Semaglutide: A New Era in GLP-1 Receptor Agonist Treatment for Type 2 Diabetes