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The formed MDA-modified -syn induces irreversible motor dysfunction, causes SN dopaminergic neuronal loss, promotes protein aggregation, and leads to other PD-like pathological features in mice
Their mood and emotional state may be unstable, and sleepwalking can lead to miscommunication or even aggression
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Although exogenous factors, including infection and inhaled pollutants, could directly oxidize GSH, endogenous disease-specific mechanisms could also prime the process
