This is consistent with published evidence showing that Epigallocatechin-3-gallate suppresses pro-apoptotic gene expression at low doses while triggering pro-apoptotic profiles at high doses 47,48 , and that high GTE concentrations ( 15 mg/L) impair sperm quality parameters in multiple species 31
We recently reported that the fructose-rich diet impacts different metabolic parameters by inducing systemic inflammation, hepatic insulin resistance, increase of plasma triglycerides [66], and leaky gut [67], which persisted after switching to control diet
Although current literature provides limited detail on pathways such as A20, SIRT1, and Nrf2, available evidence suggests that any endogenous mechanism capable of suppressing NLRP3 activation, reducing NETosis, or mitigating fibrosis has the potential to delay the transition from acute gouty inflammation to chronic tophaceous lesions (181183)
If not, do I need B separately
doi:10.1016/j.jaad.2016.04.051