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doi: 10.1016/j.biopha.2018.02.082

Among them, specifically targeting the downstream mediators of c-Met involved in tumor progression is a promising method, including the Grb2 SH2 domain, Src, MAPK, STAT3, Shp2 ( Recently endosomal processing has been demonstrated to play a pivotal role in the progression of HCC (Sorkin and von Zastrow, 2009