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The synthesis and secretion of endothelin in patients with COPD increase, 106 and during the exacerbation of COPD, the level of endothelin further rises and participates in the formation of pulmonary hypertension

Gastroenterology , 2005;129(2):512-521

Ivko OM, Drobintseva AO, Leonteva DO, Kvetnoy IM, Polyakova VO, Linkova NS

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If you need pain relief, overthecounter paracetamol or an NSAID is usually fine follow dosing instructions and check with your clinician if youre on other medicines