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Biochem Biophys Res Commun 324:9297 Lindsay JR, Duffy NA, McKillop AM et al (2005) Inhibition of dipeptidyl peptidase IV activity by oral metformin in type 2 diabetes
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The reported results are promising: Over 80% relative bioavailability Around 160 higher bioavailability vs oral tablets Sustained drug levels for ~1 week (once-weekly dosing potential) Additionally, the microneedle patches are stable at room temperature, eliminating the need for cold storage, unlike semaglutide injections
Monoacylglycerol binds to GPR119 in L cells to promote the release of GLP-1, GIP and insulin ( 2+ were observed following GPBA-R activation in single GLUTag cell, and bile acid and GPBA-RA increased GLP-1 secretion in intestinal cultures (Parker et al., 2012b)