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The researchers found that addition of vitamin C in the second stage was the optimal protocol to induce iHeps, with the iHep subpopulation of 15% in total cells ( / mice and improving liver functions in vivo in a similar manner to PHHs (Zhong et al., 2024)

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N Engl J Med 374:135145 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC (2015) NRF2 regulates serine biosynthesis in non-small cell lung cancer