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This observation, coupled with the added stability contributed by C-terminal amidation and the desire to increase the hydrophobicity of the peptide, led to the generation of a series of compounds with the structure, N-acyl-Tyr-Ile-(6) amino -hexanoic amide

This comprehensive approach likely provides greater benefits than any single intervention alone

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A preliminary study of eleven consecutive patients evaluated individuals suffering from diabetic peripheral neuropathy who were treated with a combination of L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate (active Vitamin B6)

Some patients lose 2 to 4 pounds over several months as a side effect of glucose excretion through urine