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Chronic treatment with DHF (6 g/day) in murine models demonstrated reduced eosinophilic pulmonary inflammation, serum IgE, IL-4 and IL-13 levels and an increase in IFN- production in cell cultures from the lung in response to antigen stimulation [112]

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The 2025 EMJ Dermatology scoping review reached the same conclusion: low-molecular-weight HA penetrates the dermis while high-molecular-weight HA delivers surface hydration and barrier protection