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It is generally accepted that the production of oxidants has to be strictly regulated, and that the ability of cells and organisms to adequately respond to oxidative stress is one of the main regulators of aging and lifespan [111]

Acta Paediatr

COA verification is particularly important for GHK-Cu because the active compound requires precise copper-to-peptide ratios: too little copper reduces efficacy while excess free copper in a preparation could cause local tissue irritation or contribute to systemic copper accumulation in patients with impaired copper metabolism

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When the tissue is damaged, tissue proteases break down SPARC, releasing an array of GHK and GHK-containing copper-binding peptides, which stimulate cell proliferation and new vessels growth