Until now, however, much less was known about what happens inside the neurons targeted by these drugs
2.8 Molecular mechanics-generalized born surface area (MM-GBSA) calculations MM-GBSA calculations were performed using two different tools: the Prime module (Schrodinger Release, 2021f) in the Schrdinger Maestro (Schrodinger Release, 2021e) and the fastDRH ( (Wang et al., 2022)
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Albumin leakage, for instance, can activate astrocytes and impair glutamate and potassium buffering, thereby promoting neuronal hyperexcitability
September 2025: Pfizer announced its agreement to acquire Metsera in a deal valued at up to USD 7.3 billion, strengthening its pipeline of next-generation GLP-1, amylin, and obesity therapies