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The PROMIS T -score metric is anchored to the United States general population, and a cutoff T -score of 50 differentiates clinically meaningful fatigue in the oncology population ( Metabolomics Untargeted metabolomics analysis was performed at Metabolon, Inc., (Durham, NC, United States), as previously described ( via negative ionization following elution from a HILIC column (Waters UPLC BEH Amide 2.1 150 mm, 1.7 m) using a gradient consisting of water and acetonitrile with 10 mM ammonium formate, pH 10.8