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Acknowledgements This work was supported by the Natural Science Foundation of Jiangsu province, grant number: BK20241807, the Key Research and Development Project of Hainan Province, grant number: ZDYF2022XDNY335, the collaborative Projects of Amway China Co., Limited and the National University of Singapore (Suzhou) Research Institute, (grant number: Am20230595RD)

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Unapproved: DSIP is not approved by the FDA or EMA and is for research use only not for human consumption