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Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis

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Delayed gastric emptying dilates the stomach, making more food available for reflux into the esophagus

492 Epidemiological studies have found that human GPX4 gene variants are associated with obesity and cardiovascular diseases

[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis