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doi: 10.3390/molecules27217223 220 AliRAMinarchickVCZahaviMRysengaCESturmKAHoyCKet al

Utilizing tissue-specific promoters to drive the localized expression of copper transporters or chelating proteins within specific organs (e.g., the heart) allows for fine-tuned modulation of local copper homeostasis without disrupting systemic balance [258]

[43],[44],[45],[46],[47] In addition, there is sufficient evidence demonstrating the importance of glutathione levels in the genesis of melanoma and related skin tumors

Therefore, it is not only the content of Cys, but also Met availability, that limits glutathione synthesis in some cases