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Tapering off the GLP-1 RA (rather than stopping abruptly) allows your medical team to gradually shift your medications with each decrease in your GLP-1 RA dose, helping to prevent huge spikes in blood sugar

Abbreviations ACAN: aggrecan ACTG1: actin gamma 1 ADAMST1: a disintegrin and metalloproteinase with thrombospondin motifs 1 ADAMTS4: a disintegrin and metalloproteinase with thrombospondin motifs 4 ALDOC: aldolase C ANXA1: annexin A1 BGN: biglycan BiP: binding immunoglobulin protein BSG: basigin CALU: calumenin CANX: calnexin CAPN1: calpain-1 CAPN2: calpain-2 CATB: cathepsin B CD44: cluster of differentiation 44 C1R: complement C1r subcomponent C1S: complement C1s subcomponent CNN2: calponin 2 CNN3: calponin 3 COL2A: collagen type II alpha DCN: decorin ECM: extracellular matrix ER: endoplasmic reticulum ERGIC: ER-Golgi intermediate compartment FASCN1: fascin actin-bundling protein 1 FBN1: fibrillin-1 FBLN1: fibulin-1 FBS: fetal bovine serum FC: fold change FDR: false discovery rate FN1: fibronectin 1 GSTP1: glutathione S-transferase pi 1 GO: gene ontology H 2 O 2 : hydrogen peroxide HMGB1: high-mobility group box 1 HSP70: heat shock protein 70 HSPA1B: heat shock protein family A (Hsp70) member 1B HSPA8: heat shock protein family A (Hsp70) member 8 HSP90B1: heat shock protein 90 beta family member 1 HSPG2: heparan sulfate proteoglycan 2 IL-1: interleukin-1 IL-6: interleukin-6 IL-8: interleukin-8 IL-18: interleukin-18 IGFBP: insulin-like growth factor binding protein LC-MS/MS: liquid chromatography coupled to tandem mass spectrometry LOX: lysyl oxidase LRP1: low-density lipoprotein receptor-related protein 1 LAMP2: lysosome-associated membrane protein 2 MAPK1: mitogen-activated protein kinase 1 MIF: macrophage migration inhibitory factor MMP: matrix metalloproteinase MMP1: matrix metalloproteinase 1 MMP2: matrix metalloproteinase 2 MMP13: matrix metalloproteinase 13 NHAC-Kn: normal human articular knee chondrocytes OA: osteoarthritis PBS: phosphate-buffered saline PCA: principal component analysis PCK2: phosphoenolpyruvate carboxykinase 2 PCOLCE: procollagen C-endopeptidase enhancer PDI: protein disulfide isomerase PPIA: peptidylprolyl isomerase A PRDX5: peroxiredoxin 5 PRDX6: peroxiredoxin 6 PYGB: glycogen phosphorylase B PYGL: glycogen phosphorylase L QSOX1: quiescin sulfhydryl oxidase 1 ROS: reactive oxygen species SOD2: superoxide dismutase 2 SERPINE2: serpin family E member 2 SPARC: secreted protein acidic and rich in cysteine SPTAN1: spectrin alpha non-erythrocytic 1 ST3GAL1: ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ST6GAL1: ST6 beta-galactoside alpha-2,6-sialyltransferase 1 TFA: trifluoroacetic acid TIMP1: tissue inhibitor of metalloproteinases 1 TIMP2: tissue inhibitor of metalloproteinases 2 TNC: tenascin TXNDC5: thioredoxin domain-containing protein 5 UPR: unfolded protein response VCL: vinculin YWHAE: 14-3-3 protein epsilon References Yagi M, Endo K, Komori K, Sekiya I

10.3389/fpls.2017.00192 153 SzatmriA.OttP

A Glutathione is known for supporting the bodys natural detoxification process

Thus, the MIA OA model is appropriate for studying the pharmacological effects of new drugs that can act on OA-related pain 42,43