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MR-PRESSO detected outliers in the overall associations with diabetes, LDL-cholesterol, HDL-cholesterol, apolipoprotein B and diastolic blood pressure, and sex-specific association with LDL-cholesterol, HDL-cholesterol, and apolipoprotein B (shown in Additional file 1: Table S5), where we used corrected estimates from MR-PRESSO

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Flushing occurs in about 21% and headache in 12%