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The GIP receptor activation appears to reduce nausea compared to pure GLP-1 agonists, which is why retatrutide shows a 28% nausea rate versus 44% for semaglutide despite being more potent

later submissions get a decision the next day, and weekend intakes go to the front of the line Monday morning

Initially approved for treating type 2 diabetes, they have become a go-to therapy for adults who are obese or overweight

But that little dose might not provide meaningful benefits, particularly for weight loss

Exenatide was also safe and well-tolerated, with no patients in the exenatide-treated group withdrawn due to excessive weight loss and weight loss reversed following drug cessation, within the latest trial [87]