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Results showed that 44 genes were upregulated and 43 genes were downregulated in the BV2-metformin-loaded PLGA-treated group, indicating that the treatment had a profound impact on gene expression

Unlike weekly injectable GLP-1s, where a missed dose still provides several days of drug exposure, missing a daily orforglipron dose creates a full day without therapeutic drug levels

By combining complementary LBVS and SBVS approaches and explicitly exploiting consensus across multiple methods and receptor conformations, the proposed workflow addresses key limitations of conventional single-method screening strategies when applied to structurally complex class B1 GPCRs

Two tales of antioxidant enzymes on cells and diabetes

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