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Western blot analysis To investigate the effects of the over-expression/low-expression of let-7c on the odonto/osteogenic differentiation of IGF-1 treated SCAPs, IGF-1 treated SCAPs in Con-over group, Let-7c -over group, Con-low group and Let-7c -low group were respectively cultured for 0, 3 and 7 days and then collected

Consequently, SP@M could domesticate SMs into an anti-inflammatory phenotype of M2-like, and suppress synovial inflammation in vivo (Fig

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This enhanced form of insulin-like growth factor 1 (IGF-1) is made to stay active in the body for a longer time, which makes it very useful for many different uses