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LEAP2 is also shown to bind to GHSR in a non-competitive manner to ghrelin, thereby suggesting the presence of an allosteric site on the receptor (363)

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However, research specifically on IGF-1 LR3 remains limited, and there is currently insufficient clinical evidence to conclude that it safely or effectively supports tendon or ligament healing in humans

IGF-1 LR3 research typically starts at 20 mcg daily and rarely exceeds 40 mcg in human-equivalent animal models, because the reduced IGFBP binding makes even low doses highly bioavailable