While our pharmacological approach could not distinguish between different L-type VGCCs, we speculate that CACNA1D may mediate the responses we observed, since this channel is expressed at appreciable levels in hPSC-derived POMC neurons (28 CPM) and is transcriptionally induced by semaglutide (Fig 3L
Our findings suggest that metformin has a greater predicted neuroprotective impact compared to 38 other DM2 DMTs, including semaglutide, that target the DM2-AD comorbidity network, primarily by engaging key metabolic and neuroinflammatory pathways and by indirectly modulating viral-associated mechanisms relevant to AD pathology
Activated PKA and EPAC2 can close ATP-dependent K + channels and voltage-dependent K + channels, leading to membrane depolarization and the activation of voltage-dependent calcium channels (VDCC), resulting in Ca 2+ influx
Kalinderi K, Papaliagkas V, Fidani L (2024) GLP-1 Receptor Agonists: A New Treatment in Parkinsons Disease
Es crucial para la salud del corazn y el sistema nervioso