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Absolute body weight reductions measured 10.2, 12.9, and 13.1 kg across the 2.4, 4.8, and 6 mg cohorts respectively vs

Unexpectedly, activation of p21, ICAM1, or SRXN1 was not observed (Supplementary Figure S5), although DNA (Nassini et al., 2010), and Keap1 ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study (Tafazoli and OBrien, 2009)

2 = same as 1 + diffuse expansion of interlobular septae