Moreover, IGF1R activated by IGF-1 plays a role in epidermal growth factor receptor (EGFR)-mediated primary or secondary resistance to colorectal cancer by upregulating the PI3K/AKT signaling pathway (16)
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Study-related adverse events In a 26-week, open-label study in adult patients (N=665) comparing Victoza 1.2 mg, Victoza 1.8 mg, and sitagliptin 100 mg, all in combination with metformin, the adverse reactions reported in 5% of patients treated with Victoza were nausea (23.9% vs 4.6%), headache (10.3% vs 10.0%), diarrhea (9.3% vs 4.6%), and vomiting (8.7% vs 4.1%)
Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, and Egan JM
