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A recent whole-exome sequencing analysis of six bromocriptine-resistant and six responsive prolactinomas, in addition to exclude genetic variants of DRD2 gene, revealed sequence variants associated with 10 genes selected as potentially involved in resistance, among which PRB3 (36) and PRDM2 (37) were lower in resistant prolactinomas than in the responsive tumors, but the mechanisms involved are unknown

As the condition progresses, some common symptoms may include fatigue, abdominal discomfort or bloating, pain in the upper right side of the abdomen, and unexplained weight loss

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