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Intervention groups knew they were receiving the supplements, which puts the study at a huge risk for bias

Topiramate causes weight loss primarily by suppressing appetite and reducing food intake, likely through its effects on neurotransmitter systems including GABA and glutamate pathways

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GLP-1 receptor agonists work by using your bodys natural signals to mimic a hormone it naturally produces, helping you feel fuller for longer periods and reducing unwanted cravings