The safety and effectiveness of Zepbound have not been established in pediatric patients under the age of 18
Many patients benefit from a modest increase in semaglutide dose, a protocol adjustment (such as switching from once-weekly to twice-weekly micro-dosing), or incorporation of complementary compounds that target alternative appetite or metabolic pathways
However, these synthetic DPP-IV inhibitors have been reported to have a number of adverse effects, such as gastrointestinal adverse reactions, allergic reactions, skin-related side effects, and musculoskeletal disorders
Medicare, especially, wants to see more long-term benefits
Li N, Liu BW, Ren WZ, Liu JX, Li SN, Fu SP, Zeng YL, Xu SY, Yan X, Gao YJ, Liu DF, Wang W (2016) GLP-2 attenuates LPS-induced inflammation in BV-2 cells by inhibiting ERK1/2, JNK1/2 and NF-B signaling pathways