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RNA-seq and transcriptomic analysis revealed that Auranofin and the combination with COJEC significantly downregulated pathways associated with tumor malignancy and metastatic capacity, such as MTORC1 signaling, glycolysis, Notch signaling, KRAS signaling, WNT- catenin signaling, hypoxia, angiogenesis, IL-6/JAK/STAT3 signaling, and epithelial-to-mesenchymal transition (Fig

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Among these, anti-inflammatory interventions are central, as inflammation plays a key role in exacerbating BBB permeability and neurological impairments (Cervellati et al., 2020)

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