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While adenosine triphosphate (ATP) signaling was enhanced in cultured DRG neurons treated with exendin-4, capsaicin sensitivity and calcium influx remained unaffected, suggesting GLP-1R predominantly modulating gut motility rather than pain signaling [55]

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However, these side effects werent confirmed to be associated with the treatment and could have been a coincidence and not related to the use of tesofensine

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The American Diabetes Association (ADA) guidelines emphasize avoiding unplanned cessation of glucose-lowering therapy without alternative management