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The inner photoreceptor matrix (IPM) situated between RPE and photoreceptor cells has previously been shown to have IGF-1 immunoreactivity [36] and also contains high levels of IGF-1 binding protein (IGFBP), which binds IGF-1 and regulates its availability [36]

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Interestingly, for those struggling with Type 2 diabetes, insulin resistance and additional criteria could benefit from a GLP-1 receptor agonist and may have an added benefit of improved pelvic floor muscle activation